Signs of deferasirox genotoxicity

Retroviral Genotoxicity

Gene therapies have enormous potential to cure human disease. In recent years, hematopoiet‐ ic stem cell (HSC) gene therapy has advanced tremendously, due in part to years of intense re‐ search to develop effective vectors and efficient ex vivo transduction protocols. In early clinical trials, inefficient gene transfer resulted in either a lack of therapeutic benefit or shortlived therapeutic b...

Genotoxicity of Soil

A review of the literature published on the genotoxicity of soil is presented in this report. Subheadings of the report include outlines of genotoxicity assays that have been used to examine the soil samples and methods commonly used to prepare soil samples for genotoxicity assay, and a review of the genotoxicity of soil. Soil has been grouped according to potential sources of pollution, e.g. i...

Golf Signs GOLF SIGNS

Genotoxicity of glycol ethers.

The genetic toxicology of glycol ethers is reviewed. Ethylene glycol monomethyl ether (EGME) and diglyme have been more extensively studied than other members of this series. Most results indicate a lack of genotoxic potential, but certain tests have yielded positive responses with certain compounds. Ethylene glycol monoethyl ether (EGEE) induced sister chromatid exchanges and chromosomal aberr...

Deferasirox induced liver injury in haemochromatosis.

Durg-induced liver injury is a common side-effect of many medicines. It is particularly problem when the original condition under treatment is already causing liver damage. This report describes the hepatotoxicity induced by Deferasirox in a patient with haemochromatosis with a discussion of possible pathogenetic mechanism.